Correction to: Toxicity of ayahuasca after 28 days daily exposure and effects on monoamines and brain-derived neurotrophic factor (BDNF) in brain of Wistar rats

Ayahuasca is a hallucinogenic beverage that affects the serotonergic system and have therapeutic potential for many diseases disorders, including depression drug addiction. The objectives of this study were to evaluate toxic effects ayahuasca on rats after chronic exposure, levels monoamines, their metabolites brain-derived neurotrophic factor (BDNF) in brain. Female male treated orally 28 days with H2O (control), fluoxetine (FLX), selective serotonin reuptake inhibitor antidepressant, or (Aya) at doses 0.5X, 1X 2X ritualistic dose (7 10 animals/group). Clinical, hematological macroscopic results showed was safe rats. Behavior tests conducted one hour last treatment from Aya1 group explored open field central area less than control group, number entries compared total locomotion also significantly lower FLX group. hippocampus removed BDNF analysis remaining brain used monoamine by HPLC-FL. Serotonin higher only Aya2 female while significant reduction its metabolite 5-HIAA observed Dopamine similar among experimental groups, but DOPAC increased groups controls, especially females, DOPAC/dopamine turnover HVA, another dopamine metabolite, did not change treatments HVA/DOPAC ratio all groups. Norepinephrine detected any sample, MHPG female groups controls when expressed relation weight. mechanisms involved increase serotonin, animals should be further investigated specific areas.